Research and science

Breastfeeding and breast milk are the best form of nutrition for infants. Unfortunately, the supply of breast milk is not always sufficient. The baby is underfed and as a result becomes irritable and cries, particularly in the case of premature babies. This is when we decide to include modified milk in the feeds earlier. This increases the risk of food intolerance, necrotising enterocolitis (NEC), low immunity and increased risk of infection. BC bovine colostrum is increasingly used in early life as a milk or nutritional supplement. It represents the most complete and valuable food for the newborn. It contains numerous bioactive components designed to activate the immune system and improve intestinal function. There is growing evidence that the use of colostrum in early life has many benefits in adulthood.

Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health

Sangild, P.T.; Vonderohe, C.; Melendez Hebib, V.; Burrin, D.G..

Colostrum and milk protein rankings and ratios of importance to neonatal calf health using a proteomics approach

Asger Nissen, Pia Haubro Andersen, Emøke Bendixen, Klaus Lønne Ingvartsen, Christine Maria Røntved

Detection of cytokines in bovine colostrum

Hagiwara K, Kataoka S, Yamanaka H, Kirisawa R, and Iwai H.

Bovine Colostrum Before or After Formula Feeding Improves Systemic Immune Protection and Gut Function in Newborn Preterm Pigs

Li Y., Pan X. , 1, Nguyen D.N. , Ren S., Moodley A. , Sangild P.T.

Therapeutic properties of proteins and peptides from colostrum and milk

Michał Zimecki, Jolanta Artym

Immunological role of colostrum

Karolina A. Rak, Monika Bronkowska

Health Benefits of Bovine Colostrum in Children and Adults

Harpal S.Buttar, Siddhi M.Bagwe, Sukhwinder K.Bhullar, Ginpreet

Passive immunisation, i.e. the oral consumption of immunoglobulins contained in colostrum, is of increasing importance in supporting the body with low immunity. Colostrum and its bioactive constituents are characterised by a broad spectrum of activity showing antibacterial, antiviral, antiparasitic, antifungal, anticancer and anti-inflammatory properties. There is growing evidence that regular supplementation with colostrum has reduced the number of flu-like episodes, upper respiratory tract infections (URTIs) and episodes of diarrhoea. Colostrum provides an alternative to antibiotics with the potential to reduce the need to take them.

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection

Laurien H. Ulfman, Jeanette H. W. Leusen, Huub F. J. Savelkoul, John O. Warner, R. J. Joost van Neerven

Bovine Colostrum Treatment of Specific Cancer Types: Current Evidence and Future Opportunities

Ahmad R. Alsayed, Luai Z. Hasoun, Heba A. Khader, Iman A. Basheti, Andi Dian Permana

Immunological role of colostrum

Karolina A. Rak, Monika Bronkowska

Bovine Colostrum: Its Constituents and Uses

Raymond John Playford, Michael James Weiser

Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children

Maciej Hałasa, Karolina Skonieczna-Żydecka, Bogusław Machaliński, Leonard Bühner, Magdalena Baśkiewicz-Hałasa

Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth

Samuel M., Chisanga D., Liem M., Keerthikumar S., Anand S., Ang C.-S., et al.

Therapeutic potentials of bovine colostrums

B R Thapa

Bovine colostrums: a review of clinical uses

Gregory S Kelly

Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical management of COVID-19

Alyne Batista da Silva Galdino, Adriano Henrique do Nascimento Rangel,
Harpal Singh Buttar, Manuela Sales Lima Nascimento, Elaine Cristina Gavioli, Riva de Paula Oliveira, Danielle Cavalcanti Sales, Stela Antas Urbano & Katya Anaya

Leaky gut is called a condition in which excessive components of the food content enter the bloodstream through a damaged or leaky epithelium of the intestinal mucosa. These may include harmful microorganisms, fungi and other antigens. In a healthy body, these elements do not penetrate the natural intestinal-blood barrier. We are then talking about maintaining an airtight intestinal barrier, in which bacteria, undigested macronutrients and other molecules that cause activation of the immune system remain in the intestine and do not penetrate the bloodstream. In light of recent research, it appears that the highest quality colostrum has an incredibly effective ability to increase the tightness of the intestinal-blood barrier.

Bovine colostrum as a biologic in clinical medicine

Struff WG, Sprotte G.

Role of colostrum in gastrointestinal infections

Pawan Rawal , Vineet Gupta, B R Thapa

Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders

Playford RJ, Macdonald CE, and Johnson WS

Bovine Colostrum: Its Constituents and Uses

Raymond John Playford, Michael James Weiser

Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes

Maciej Hałasa, Dominika Maciejewska, Magdalena Baśkiewicz-Hałasa, Bogusław Machaliński, Krzysztof Safranow, Ewa Stachowska

Health factors in colostrum

B R Thapa

The intense physical exertion involved in sports puts excessive strain on the body. There is then a risk of frequent injuries, low immunity and a decrease in performance. Colostrum, with its components such as growth factors, immunoglobulins, cytokines, lactoferrin and hormones, can provide support for the body and accelerate post-workout regeneration. It has the ability to reduce inflammatory processes resulting from micro-damage to muscle fibres caused during training. In exemplary studies, colostrum has been shown to have a positive effect on biochemical parameters, physical performance, regeneration, strengthening muscle mass and improving intestinal leakage. As a result, colostrum supplementation can significantly improve sports performance. According to analysts, the market for colostrum sales will grow rapidly.

Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training

A Mero, H Miikkulainen, J Riski, R Pakkanen, J Aalto, T Takala

A low-dose, 6-week bovine colostrum supplementation maintains performance and attenuates inflammatory indices following a Loughborough Intermittent Shuttle Test in soccer players

Yiannis Kotsis, Anastasia Mikellidi, Cleopatra Aresti, Eleni Persia, Aristomenis Sotiropoulos, Demosthenes B. Panagiotakos, Smaragdi Antonopoulou, Tzortzis Nomikos

The Use of Bovine Colostrum in Sport and Exercise

Glen Davison

The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women

Jose Antonio, Michael S. Sanders, Darin Van Gammeren

The influence of bovine colostrum supplementation on exercise performance in highly trained cyclists

C M Shing, D G Jenkins, L Stevenson, and J S Coombes

Bovine colostrum sales set to soar amongst sports nutrition boom

Nikki Hancocks

A Systematic Review of the Influence of Bovine Colostrum Supplementation on Leaky Gut Syndrome in Athletes: Diagnostic Biomarkers and Future Directions

Hanna Dziewiecka , Harpal S. Buttar, Anna Kasperska, Joanna Ostapiuk-Karolczuk,
Małgorzata Domagalska, Justyna Cichoń, Anna Skarpańska-Stejnborn

Potential use of colostrum bovinum supplementation in athletes

Head N, Voznevich M.

Colostrum contains viable cells , including growth factors, lactoferrin, macrophages, lysozyme, which show beneficial effects in the development and regeneration of skin cells and reduce skin inflammation. Exosomes derived from colostrum have the potential to protect and strengthen hair follicles, which can be rejuvenated. A unique growth factor is EGF, classified as an epidermal cytokine, which acts to stimulate and repair the epidermis. Milk cytokines accelerate wound healing, improve skin nutrition and hydration, stimulate the division of the epidermal creative layer and its normal growth. These properties are used in cosmetology and trichology.

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

Donatello Castellana, Ralf Paus, Mirna Perez-Moreno

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

Hyosuk Kim, Yeongji Jang, Eun Hye Kim, Hochung Jang, Haeun Cho, Geonhee Han, Hyun Kyu Song, Sun Hwa Kim, Yoosoo Yang

Harnessing the Natural Healing Power of Colostrum: Bovine Milk-Derived Extracellular Vesicles from Colostrum Facilitating the Transition from Inflammation to Tissue Regeneration for Accelerating Cutaneous Wound Healing

Kim H., Kim D. E., Han G., Lim N. R., Kim E. H., Jang Y., et al.

Bovine Colostrum: Its Constituents and Uses

Raymond John Playford, Michael James Weiser

Colostrum contains a diverse range of bioactive components suitable for the development of functional foods, nutraceuticals and pharmaceuticals with veterinary and health applications. It has a strong safety profile with applications in all age groups for the promotion of health and the alleviation of various disease states. Bovine colostrum-based products play a noteworthy role in the development of innovative products to promote health and prevent chronic diseases. Increased global milk production and new processing technologies have resulted in significant growth in the market for colostrum-based products.

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

Rahul Mehra , Renu Garhwal, Karnam Sangwan, Raquel P. F. Guiné , Edite Teixeira Lemos, Harpal Singh Buttar, Pradeep Kumar Singh Visen, Naveen Kumar, Anuradha Bhardwaj, Harish Kumar

Bovine Colostrum for Veterinary and Human Health Applications

Kevin Linehan

Scientific Opinion on bovine lactoferrin

EFSA Journal, 24.05.2012

Bovine Colostrum and Its Potential for Human Health and Nutrition

Ays¸enur Arslan, Merve Kaplan, Hatice Duman,, Ays¸e Bayraktar , Melih Ertürk, Bethany M. Henrick , Steven A. Frese and Sercan Karav

The use of colostrum has a major impact on the quality of husbandry and the promotion of the health of farm animals as well as domestic animals. It provides support to the body by strengthening immunity and stabilising the intestinal flora. It leads to improved development of the digestive tract and promotes the regeneration of damaged intestinal mucosa cells. BC supplementation in newborn animals reduced mortality and reduced morbidity in adulthood. It showed benefits in terms of faster growth, better breeding parameters, reduced medical costs and, importantly for sport animals, enabled better performance.

Bovine Colostrum: Its Constituents and Uses

Raymond John Playford, Michael James Weiser

Importance of colostrum supply and milk feeding intensity on gastrointestinal and systemic development in calves

Hammon, H.M.; Liermann, W.; Frieten, D.; Koch, C.

The effect of tube versus bottle feeding colostrum on immunoglobulin G absorption, abomasal emptying, and plasma hormone concentrations in newborn calves

Desjardins-Morrissette, M., J.K. van Niekerk, D. Haines, T. Sugino, M. Oba, and M.A. Steele

Bovine colostrum supplementation optimises earnings, performance and recovery in racing Thoroughbreds

C.K. Fenger, T. Tobin, P.J. Casey, E.A. Roualdes, J.L. Langemeier, D.M. Haines

Nutritional and Functional Properties of Colostrum in Puppies and Kittens

Luciana Rossi, Ana Elena Valdez Lumbreras, Simona Vagni, Matteo Dell'Anno, Valentino Bontempo

Supplementation of diets with bovine colostrum influences immune function in dogs

Satyaraj E., Reynolds A., Pelker R., Labuda J., Zhang P., Sun P.

Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets

Sugiharto Sugiharto, Ann-Sofie Riis Poulsen, Nuria Canibe, Charlotte Lauridsen

Bovine colostrum as a natural growth promoter for newly weaned piglets

Christelle Boudry, Jean-Paul Dehoux, Daniel Portetelle & André Buldgen

Effects of bovine colostrum on performance, survival, and immunoglobulin status of suckling piglets during the first days of life

M. Viehmann , C. Unterweger , M. Ganter , B.U. Metzler-Zebeli, M. Ritzmann , I. Hennig-Pauka

Effects of spray-dried colostrum and plasmas on the performance and gut morphology of broiler chickens

M. R. King, V. Ravindran, P. C. H. Morel, D. V. Thomas, M. J. Birtles, J. R. Pluske

The Effect of Colostrum Powder Supplementation on Performance, Intestinal Morphology, Blood Biochemical Parameters, Immunity and Antioxidant Status of Broilers

M.H. Gorbannejhad Parapary, A. Nobakht, Y. Mehmannavaz

The Effect of Using Bovine Colostrum and Probiotics on Performance, Egg Traits, Blood Biochemical and Antioxidant Status of Laying Japanese Quails

Reza Mokhtarian Asl, Ali Nobakht, Valiollah Palangi, Aristide Maggiolino, Gerardo Centoducati

Supplementation of Diets With Bovine Colostrum Influences Immune and Gut Function in Kittens

Asa M. Gore, Ebenezer Satyaraj, Jeff Labuda, Robyn Engler, Peichuan Sun, Wendell Kerr and Lisa Conboy-Schmidt

Supplementation of diets with bovine colostrum influences immune function in dogs

Ebenezer Satyaraj, Arleigh Reynolds, Robyn Pelker, Jeff Labuda, Peifang Zhang and Peichuan Sun

Research and science

Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health

Colostrum and milk protein rankings and ratios of importance to neonatal calf health using a proteomics approach

Detection of cytokines in bovine colostrum

Bovine Colostrum Before or After Formula Feeding Improves Systemic Immune Protection and Gut Function in Newborn Preterm Pigs

Therapeutic properties of proteins and peptides from colostrum and milk

Immunological role of colostrum

Health Benefits of Bovine Colostrum in Children and Adults

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection

Bovine Colostrum Treatment of Specific Cancer Types: Current Evidence and Future Opportunities

Immunological role of colostrum

Bovine Colostrum: Its Constituents and Uses

Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children

Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth

Therapeutic potentials of bovine colostrums

Bovine colostrums: a review of clinical uses

Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical management of COVID-19

Bovine colostrum as a biologic in clinical medicine

Role of colostrum in gastrointestinal infections

Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders

Bovine Colostrum: Its Constituents and Uses

Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes

Health factors in colostrum

Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training

A low-dose, 6-week bovine colostrum supplementation maintains performance and attenuates inflammatory indices following a Loughborough Intermittent Shuttle Test in soccer players

The Use of Bovine Colostrum in Sport and Exercise

The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women

The influence of bovine colostrum supplementation on exercise performance in highly trained cyclists

Bovine colostrum sales set to soar amongst sports nutrition boom

A Systematic Review of the Influence of Bovine Colostrum Supplementation on Leaky Gut Syndrome in Athletes: Diagnostic Biomarkers and Future Directions

Potential use of colostrum bovinum supplementation in athletes

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

Harnessing the Natural Healing Power of Colostrum: Bovine Milk-Derived Extracellular Vesicles from Colostrum Facilitating the Transition from Inflammation to Tissue Regeneration for Accelerating Cutaneous Wound Healing

Bovine Colostrum: Its Constituents and Uses

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

Bovine Colostrum for Veterinary and Human Health Applications

Scientific Opinion on bovine lactoferrin

Bovine Colostrum and Its Potential for Human Health and Nutrition

Bovine Colostrum: Its Constituents and Uses

Importance of colostrum supply and milk feeding intensity on gastrointestinal and systemic development in calves

The effect of tube versus bottle feeding colostrum on immunoglobulin G absorption, abomasal emptying, and plasma hormone concentrations in newborn calves

Bovine colostrum supplementation optimises earnings, performance and recovery in racing Thoroughbreds

Nutritional and Functional Properties of Colostrum in Puppies and Kittens

Supplementation of diets with bovine colostrum influences immune function in dogs

Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets

Bovine colostrum as a natural growth promoter for newly weaned piglets

Effects of bovine colostrum on performance, survival, and immunoglobulin status of suckling piglets during the first days of life

Effects of spray-dried colostrum and plasmas on the performance and gut morphology of broiler chickens

The Effect of Colostrum Powder Supplementation on Performance, Intestinal Morphology, Blood Biochemical Parameters, Immunity and Antioxidant Status of Broilers

The Effect of Using Bovine Colostrum and Probiotics on Performance, Egg Traits, Blood Biochemical and Antioxidant Status of Laying Japanese Quails

Supplementation of Diets With Bovine Colostrum Influences Immune and Gut Function in Kittens

Supplementation of diets with bovine colostrum influences immune function in dogs

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